Mapping of the human adenylosuccinate lyase (ADSL) gene to chromosome 22q13.1→q13.2
- 1 January 1993
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 64 (3-4) , 201-203
- https://doi.org/10.1159/000133575
Abstract
Adenylosuccinate lyase (ADSL) is an essential enzyme involved in de novo purine biosynthesis. A deficiency in ADSL in humans has been shown to predispose to a neuro-developmental syndrome with autistic features. Using both a somatic cell hybrid mapping panel and fluorescence in situ hybridization, we have precisely localized the human ADSL gene to chromosome 22q13.1→q13.2.Keywords
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