Malignant hyperthermia in pigs: A search for abnormalities in Ca2+ binding proteins
Open Access
- 7 March 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 153 (1) , 81-87
- https://doi.org/10.1016/0014-5793(83)80123-9
Abstract
Malignant hyperthermia occurs in man and pigs as a hereditary disorder notably as a complication of halotane‐induced anaesthesia. It involves an abnormality in the metabolism of Ca2+. A search was made for abnormalities of calcium‐binding proteins. Troponin C from normal pig muscle was found to differ in 2 of 159 amino acids from rabbit Tn C and 3 from man. No differences between normal and abnormal pig muscle were found. Two‐dimensional electrophoresis of red cell calmodulin from normal and abnormal pigs also failed to demonstrate a difference.Keywords
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