Tolerance to Bacterial Endotoxin Produced by Proliferation of Gram Negative Bacteria in the Kidney

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Abstract
The pyrogenic response to Salmonella enteriditis endotoxin was determined in rabbits made pyelonephritic by unilateral ureteral ligation and the intravenous injection of Escherichia coli and in sham operated control rabbits given an equivalent endotoxin challenge with formalin killed bacteria. Two weeks after the induction of pyelonephritis, the febrile response to endotoxin challenge was significantly less (T10=8.78,P <.001) in rabbits with pyelonephritis (13[plus or minus]5.5 fever units) than among the controls (45[plus or minus]6.01 fever units). A striking difference in the pattern of the fever curves exhibited by the pyelonephritic and control rabbits was also apparent.

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