ISOBUTENE FORMATION DURING HALOTHANE ANAESTHESIA IN MAN

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Abstract
Lipid peroxidation is thought to play a role in halothane-induced liver injury. This reaction can be monitored by measurement of ethane concentrations in expired air. The concentrations of volatile hydrocarbons were studied in breath samples from patients before and after anesthesia. In patients to whom halothane was administered, there was a significant increase in the concentration of isobutene (from 0.43 .+-. 0.09-4.66 .+-. 2.22 nmol/l). There was no change in the concentration of isobutene in 6 patients anesthetized with ketamine and diazepam. The concentrations of ethane and pentane were not altered significantly in either group.