Adhesion Molecules in Inflammatory Diseases
- 1 January 1998
- journal article
- review article
- Published by Springer Nature in Drugs
- Vol. 56 (6) , 977-988
- https://doi.org/10.2165/00003495-199856060-00003
Abstract
Cell adhesion molecules (CAM) have a key role in the inflammatory response. Selectins, integrins and immunoglobulin (Ig) gene superfamily adhesion receptors mediate the different steps of the migration of leucocytes from the bloodstream towards inflammatory foci. The activation of endothelial cells (EC) upregulates the expression of several CAM and triggers the interaction of these cells with leucocytes. Selectins are involved in the initial interactions (tethering/rolling) of leucocytes with activated endothelium, whereas integrins and Ig superfamily CAM mediate the firm adhesion of these cells and their subsequent extravasation. During rolling, leucocytes are activated through the intracellular signals generated by CAM and chemokine receptors. Blockade of the function or expression of CAM has emerged as a new therapeutic target in inflammatory diseases. Different drugs are able to interfere with cell adhesion phenomena. In addition, new antiadhesion therapeutic approaches (blocking monoclonal antibodies, soluble receptors, synthetic peptides, peptidomimetics, etc.) are currently in development.Keywords
This publication has 93 references indexed in Scilit:
- Human Chemokines: An UpdateAnnual Review of Immunology, 1997
- Adhesion Molecules — Blood Vessels and Blood CellsNew England Journal of Medicine, 1996
- Novel Antithrombotic Drugs in DevelopmentDrugs, 1995
- Inhibition of NF-κB by Sodium Salicylate and AspirinScience, 1994
- The α4β1/VCAM-1 adhesion pathway in physiology and diseaseResearch in Immunology, 1993
- Signal transduction from the extracellular matrix.The Journal of cell biology, 1993
- AsthmaNew England Journal of Medicine, 1992
- The Pathophysiology of Tumor Necrosis FactorsAnnual Review of Immunology, 1992
- Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys.Journal of Clinical Investigation, 1991
- Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell LocomotionAnnual Review of Immunology, 1991