Influence of medroxyprogesterone acetate (Provera) on plasma growth hormone levels and on carbohydrate metabolism

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Abstract
Six elderly ovariohysterectomized dogs were given medroxyprogesterone acetate (MPA 10 mg/kg body wt) at 3 wk intervals in a total of 5 injections. Mean growth hormone (GH) levels increased significantly after the 3rd injection, continued to increase slightly after the 4th and 5th injections and remained significantly elevated over control levels as late as 16 wk after the last MPA administration (P < 0.05). The mean glucose concentrations during i.v. glucose tolerance tests (IVGTT) were significantly elevated at 30, 45 and 60 min after a glucose load when performed after the 3rd MPA injection. Following the 2nd MPA injection, mean insulin levels were significantly elevated at rest, 30 and 45 min after glucose load. After the 4th and 5th MPA injections, mean insulin levels during IVGTT were significantly elevated at 30 min only. After a lag phase of several weeks MPA induces moderate GH increase in ovariohysterectomized dogs and MPA administration causes moderate disturbance of glucose homoeostasis.

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