Serum Thyroid Hormones and Thyrotropin in Anorexia Nervosa
- 1 February 1975
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 40 (2) , 334-338
- https://doi.org/10.1210/jcem-40-2-334
Abstract
Sixteen patients with typical signs and symptoms of anorexia nervosa were studied with measurement of serum thyroxine (T4), triiodothyronine (T3) and thyrotropin (TSH), both baseline and stimulated by thyrotropin-releasing hormone (TRH). The results of the patients were compared with those of 16 normal control subjects. Serum T4 (5.8 ± 0.26 μg/100 ml, mean ± se) and T3 (82 ± 5.7 ng/100 ml) of patients with anorexia nervosa were significantly (P < 0.001) lower thanthose of control subjects (T4 7.7 ± 0.32 μg/100 ml and T3 158 ± 4.7 ng/100 ml respectively). Furthermore, the ratio of T3/T4 (1.48 ± 0.243 × 10−2) inanorexia nervosa was also lower than that of control subjects (2.21 ± 0.093 × 10−2) (P < 0.001). Basalserum TSH was within normal or below the limits of detection. TSH and T3 rose after administration of TRH. The peak values of TSH were observed after 60 to 120 min, instead of 30 min normally seen after TRH injection.Keywords
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