Evidence for a Direct Pituitary Inhibition by Free Fatty Acids of in vivo Growth Hormone Responses to Growth Hormone-Releasing Hormone in the Rat
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 53 (2) , 185-189
- https://doi.org/10.1159/000125716
Abstract
The aim of this study was to determinate whether elevations in circulating free fatty acids (FFA) inhibit in vivo growth hormone (GH) responses to GH-releasing hormone (GHRH) by increasing hypothalamic somatostatin release or by acting directly on the pituitary. Thus, we have studied the effect of an Intralipid-heparin infusion on in vivo GH responses to GHRH in normal rats, normal rats passively immunized with antisomatostatin antiserum, rats with medial hypothalamic ablation, and hypophysectomized rats bearing two hypophyses under the renal capsule. Administration of 1 ml of Intralipid (500 µl at -30 min and 500 µl at -25 min) plus heparin (50 IU at-15 min) induced a marked decrease in GH responses to both 1 and 5 µg/kg of GHRH (pKeywords
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