The Use of IgM Anti‐D Coated Cells in the Deliberate Immunisation of Rh‐Negative Male Volunteers

Abstract
Attempts to produce anti‐D in rhesus‐negative men using reconstituted frozen rhesus‐positive cells were unsuccessful. The use of cells coated with IgM anti‐D for immunisation stimulates anti‐D production, and a comparison between two groups, one having cells coated with IgM anti‐D, and the other having identical cells without coating suggests that there is an enhancement of the immune response when IgM‐coated cells are used.