EFFECTS OF SOTALOL IN 20 PATIENTS WITH CARDIAC-ARRHYTHMIAS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (6) , 275-278
Abstract
Sotalol [D1-4-(2-ixopropylamine-1-hydroxyethyl)methane sulfonamide hydrochloride] was given i.v. at doses of 20-60 mg to 20 selected patients with various cardiac arrhythmias. Of these patients, 10 subsequently received oral sotalol at doses of 80-160 mg twice a day. The drug was beneficial in 2 of 2 patients with sinus tachycardia and in 4 of 7 patients with other supraventricular tachycardias. The drug was particularly effective in lidocaine-resistant ventricular arrhythmias since it was effective in 9 of 11 patients. The blood pressure of the 4 patients who were hypertensive was significantly lowered while that of the normotensive patients was not affected. Three patients who suffered from severe myocardial disease developed sinus bradycardia, which was life-threatening in 2 of them.