RADIOAUTOGRAPHIC STUDIES OF THE PROTEIN SYNTHESIS IN RAT DURING PROTEIN DEPRIVATION AND STARVATION

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Abstract
Protein-fed, protein-deprived and starved rats were administered either methionine-H3 or leucine-H3 and sacrificed 3 hours later. Radio-autographs were prepared and grain counts performed in several organs. The results indicate a shift of protein synthesis during protein deficiency from less essential to more essential organs. For the liver the shift was more marked in the experiment with leucine than in that with methionine. This can be explained on the basis that the largest change occurs in the microsomes which are rich in leucine but poor in methionine. During protein deficiency there is a heavily increased labelling of ribonucleic acid and of protein in the liver.

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