HANDLING OF TRIAMTERENE BY ISOLATED PERFUSED RAT-KIDNEY

Google Scholar
  • 1 January 1978
    • journal article
    • research article
    • Vol. 206  (3) , 701-709
Abstract
Quantitative studies on the renal handling of [3H]triamterene [a diuretic] were performed in an isolated perfused rat kidney with near normal function and in an isolated kidney with negligible filtration rate, but preserved perfusate flow rate. The excretory pattern for [3H]triamterene is compatible with that of other weak bases such as quinine and quinacrine. Tubular secretion of [3H]triamterene is strongly inhibited by anoxia and iodoacetate. Tubular reabsorption of [3H]triamterene becomes pronounced when the urine is alkaline. Clearances were reported with and without correction for perfusate albumin binding which is about 75%. Bidirectional transport processes are operative in that [3H]triamterene is secreted by the renal tubule and passively diffuses back across the tubular epithelium by a pH-dependent mechanism.

This publication has 1 reference indexed in Scilit: