Antiglomerular basement membrane nephritis after solvent exposure

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Abstract
A rapidly progressive glomerulonephritis with definitive anuria was observed after solvent inhalation in 2 young women, aged 22 and 17 yr. In both cases the renal biopsy specimen showed diffuse epithelial crescents in all glomeruli, with linear deposits of Ig[immunoglobulin]G along the glomerular basement membrane (GBM). High circulating anti-GBM antibody levels were found in sera by indirect immunofluorescence and radioimmunoassay. No anti-alveolar basement membrane antibodies were detectable by immunofluorescent microscopy in 1 patient. The solvent inhalation probably resulted in a chemical alteration of the alveolar basement membrane giving rise to anti-basement membrane antibodies, some of which may have cross-reacted with the GBM and initiated the glomerulonephritis.

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