Effects of parathroid hormone and calcitonin on plasma and nephrogenous cclic adenosine‐3.,5 ‐monophosphate in normal subjects and in pathological conditions

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Abstract
To evaluate the response of bone cells and kidney to parathyroid hormone (PTH) and calcitonin (CT), the acute effects of these hormones given i.v. on plasma c[cyclic]AMP, nephrogenous cAMP and clearance ratio (cAMP:creatinine) were studied in normal subjects and in patients with Paget''s disease, hypoparathyroidism and osteopetrosis. Subjects (25) were given bovine synthetic PTH, 38 calcitonin (16 salmon, 18 human and 4 porcine CT). In normal subjects and in patients with Paget''s disease and hypoparathyroidism plasma cAMP increased within 1 h following PTH i.v. infusion. The same dose of PTH failed to produce any increase in plasma cAMP level in 2 children with marble bone disease. Nephrogenous cAMP increased in all cases. A different relative potency of CT in increasing plasma cAMP was observed in normal subjects, according to previous results on the plasma Ca lowering effect. Paget''s disease patients showed a greater increase in plasma cAMP following infusion than normal subjects. The measurement of nephrogenous cAMP and the clearance ratio (cAMP: creatinine) demonstrated a minor involvement of the kidney in the production of cAMP after CT infusion; the late increase observed in nephrogenous cAMP was probably due to a parathyroid rebound following the hypocalcemic effect of CT.