Carbonic Anhydrase Inhibitors. Part 551 Metal Complexes of 1,3,4‐Thiadiazole‐2‐Sulfonamide Derivatives: In Vitro InhibitionStudies With Carbonic Anhydrase Isozymes I, II and IV
Open Access
- 1 January 1998
- journal article
- research article
- Published by Wiley in Metal-Based Drugs
- Vol. 5 (2) , 103-114
- https://doi.org/10.1155/mbd.1998.103
Abstract
Coordination compounds of 5-chloroacetamido-1,3,4-thiadiazole-2-sulfonamide (Hcaz) with V(IV), Cr(lll), Fe(ll), Co(ll), Ni(ll) and Cu(ll) have been prepared and characterized by standard procedures (spectroscopic, magnetic, EPR, thermogravimetric and conductimetric measurements). Some of these compounds showed very good in vitro inhibitory properties against three physiologically relevant carbonic anhydrase (CA)isozymes, i.e., CA I, II, and IV. The differences between these isozymes in susceptibility to inhibition by these metal complexes is discussed in relationship to the characteristic features of their active sites, and is rationalized in terms useful for developing isozyme-specific CA inhibitors.Keywords
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