Localization and Turnover Rate of Rat Renal ‘Dendritic’ Cells

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Abstract
The turnover rate of rat renal dendritic cells was analyzed by irradiation and bone marrow transplantation and by visualizing the dendritic cells double indirect immunofluorescence and peroxidase assays. Interstitial dendritic cells disappear from rat renal tissue shortly after irradiation: after 7 days they can be seen again. However, since the renal proximal tubular cells also simultaneously lose and regaintheir class II contents, it is assumed that irradiation has resulted in the disappearance of the Ia antigen, not the dendritic cells proper. After allogeneic bone marrow transplantation, bone marrow-derived dendritic cells appear in renal tissue between days 7-10, indicating a relatively fast turnover rate of these cells of vivo.