Biosynthesis of aristolochic acid

Abstract
The biosynthesis of aristolochic acid-1 (1) was studied in Aristolochia sipho. Tyrosine, dopa, dopamine, and noradrenaline serve as specific precursors. The nitro group of aristolochic acid is derived from the amino group of tyrosine. The aristolochic acids are yet another group of natural products related to norlaudanosoline.

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