EFFECTS OF L-GLUTAMINE ON ACETYLSALYCYLIC ACID INDUCED GASTRIC LESIONS AND ACID BACK DIFFUSION IN DOGS

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Abstract
Effects of L-glutamine on acetylsalicylic acid (ASA)-induced gastric mucosal lesions were studied in mongrel dogs. When oral ASA at 1.0 or 2.0 g/dog is given in 2 divided doses, there is severe and consistent dose-dependent mucosal damage in the glandular portion of the stomach in fasted dogs. When L-glutamine 2.0 or 4.0 g/dog in 2 divided doses is given concomitantly with ASA 2.0 g/dog orally, the gastric irritation is significantly inhibited. Instillation of 20 mM of ASA in 100 mM HCl solution into the Heidenhain pouch of Beagle dogs produced a H+ significant loss from the pouch and a Na+ gain in the lumen compared with ASA-free controls. When L-glutamine (100 mM) was given concomitantly with ASA (20 mM) into the pouch, changes of electrolyte fluxes in response to ASA alone were significantly suppressed. L-Glutamine [50 mM] had no appreciable effect on acid back diffusion caused by ASA 20 mM. The amino acid itself had little effect on the ionic movement in the pouch. Gross bleeding from the pouch treated with ASA was never observed with the concomitant dosing of ASA and L-glutamine 50 or 100 mM.