Effect of Vagotomy on Gastric Secretion and Emptying Time in Dogs

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Abstract
Bilateral transthoracic vagotomy in the dog produced these effects: (a) The appearance of free HC1 in the secretion under basal conditions occurred with the same frequency as before vagotomy but the rate of secretion diminished. (b) The acid secretory response to hypoglycemia induced by insulin was abolished in all animals, and in those tested as long as 1 year after vagotomy no return of response was seen. (c) The response to a standard dose of histamine was, on the average, decreased by about 30%. (d) The response to a standard dose of Urecholine was also reduced. (e) The response to 16A (5([gamma],[gamma] dimethylallyl)-5-ethyl barbituric acid) was abolished. (f) Higher doses of histamine or histamine and Urecholine raised the secretory rate to or above the prevagotomy level. Apparently, the depression folowing vagotomy involved a decreased sensitivity to stimulation rather than a depressed secretory capacity. (g) The greatest depression of acid secretion occurred at the 6-month postvagotomy examination period. In most of the dogs there was a tendency for the responses to both histamine and Urecholine to rise to or above the prevagotomy control level by 12 months postvagotomy. (h) The emptying of a liquid meal (boiled milk) was more rapid after vagotomy. However, the addition of fat to the meal still caused as great a delay in emptying after as before vagotomy.