Mechanism of action of voltage‐gated K+ channel antibodies in acquired neuromyotonia
- 31 August 2004
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 56 (3) , 440-444
- https://doi.org/10.1002/ana.20221
Abstract
Acquired neuromyotonia (ANM) is associated with antibodies to voltage‐gated K+ channels (VGKCs). ANM sera reduce the number of K+ currents in neuronal cell lines, but it is not clear how the antibodies act. Here, we show by using the NB‐1 cell line that the reduction in K+ currents by IgG is independent of added complement. IgG Fc and Fab fragments from ANM sera had no effect, but three of four ANM F(ab′)2 fragments significantly reduced K+ currents. Thus, cross‐linking of the channels by divalent antibodies is likely to be an important mechanism in reducing K+ currents. Ann Neurol 2004;56:440–444Keywords
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