Plasma lipids in a London population and their relation to other risk factors for coronary heart disease.

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Abstract
Fasting plasma total cholesterol and triglyceride concentrations and high-density lipoprotein (HDL)-cholesterol concentrations were measured in a random sample of 502 men and 503 women London [England] local government employees aged 16-64 yr. In subjects aged 35-54 yr, the frequency of hypercholesterolemia, defined by 1 recently recommended criterion plasma cholesterol .gtoreq. 7.1 mmol/l, was 28.0% in the men and 30.4% in the women. The frequency of hypertriglyceridemia (plasma triglyceride .gtoreq. 2.0 mmol/l) in the same group was 24.8% for the men and 6.0% for the women. In the whole sample of 1005, there was no case of the WHO Type III lipoprotein abnormality and only 1 example of the WHO Type V abnormality. The method of spline function analysis showed unimodality in the 2-dimensional cholesterol/triglyceride frequency distribution for men and women. Using multiple regression analysis, total cholesterol was independently, positively related to log10-triglyceride, HDL-cholesterol and age. Log10-triglyceride was related positively to total cholesterol, body mass index, systolic blood pressure, uric acid and fasting blood sugar in both sexes. Mean HDL-cholesterol concentrations were significantly higher in women compared with men only in the 45-64 age range. By multiple regression analysis, HDL-cholesterol was independently positively related to total cholesterol and negatively related to log10-triglyceride in both sexes, and positively related to age in women.