Positive Predictive Value of Gen-Probe APTIMA Combo 2 Testing for Neisseria gonorrhoeae in a Population of Women with Low Prevalence of N. gonorrhoeae Infection
Open Access
- 1 November 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 39 (9) , 1387-1390
- https://doi.org/10.1086/424880
Abstract
We collected specimens from women who tested positive for Neisseria gonorrhoeae using the Gen-Probe APTIMA Combo 2 (AC2), and we performed confirmatory tests using a nucleic acid amplification test (NAAT) that targets alternate gonococcal nucleic acid sequences. Among 59,664 specimens, 280 (0.47%) had positive results using AC2; 265 of these specimens were tested using the confirmatory NAAT, of which 258 yielded positive results (positive predictive value, 97.4%; 95% confidence interval, 95.1%–98.8%). Routine confirmatory testing of specimens with positive AC2 gonorrhea test results is not indicated.Keywords
This publication has 5 references indexed in Scilit:
- False‐Positive Gonorrhea Test Results with a Nucleic Acid Amplification Test: The Impact of Low Prevalence on Positive Predictive ValueClinical Infectious Diseases, 2004
- Gonorrhea Prevalence and Coinfection With Chlamydia in Women in the United States, 2000Sexually Transmitted Diseases, 2003
- Confirmation by 16S rRNA PCR of the COBAS AMPLICOR CT/NG Test for Diagnosis of Neisseria gonorrhoeae Infection in a Low-Prevalence PopulationJournal of Clinical Microbiology, 2002
- Evaluation of Laboratory Testing Methods for Chlamydia trachomatis Infection in the Era of Nucleic Acid AmplificationJournal of Clinical Microbiology, 2001
- Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by Enzyme Immunoassay, Culture, and Three Nucleic Acid Amplification TestsJournal of Clinical Microbiology, 2001