THE SURVIVAL OF SKIN ALLOGRAFTS AND XENOGRAFTS IN GERM-FREE MICE

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Abstract
SUMMARY Germ-free (BALB/c X C57BL/10)F1 and BALB/c female mice and age-matched, conventional controls were challenged with mouse skin allografts of varying degrees of histoincompatibility: “strong” (H-2), “moderate” (non-H-2), and “weak” (H-Y) and with rat skin xenografts. No significant difference in survival times of first- or secondset grafts was found between the germ-free recipients and their conventional counterparts. Apparently, neither the absence of viable microorganisms nor the reduction of lymphoid tissue in germ-free mice has an effect on skin allograft and xenograft rejection.

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