Extended-spectrum ^|^beta;-lactamase (ESBL) Produced by Escherichia coli and Klebsiella pneumoniae Isolated from Teikyou University Hospital The First Report

Abstract
We studied the cefotaxime (CTX)-resistant (MIC≥32 μg/ml) clinical isolates of E. coli and K. pneumoniae in Teikyo University Hospital from 1990 to 1996. The incidence of CTX-resistant isolates was 0.4% (6/1, 282) in E. coli and 0.6% (7/1, 044) in K. pneumoniae, in 1990. In 1995, the incidence of CTX-resistance increased to 1.7% (50/2, 910) in E. coli (p=0.0013) and 7.2% (144/1, 996) in K. pneumoniae (p512μg/ml, 8μg/ml, >512μg/ml, 8μg/ml, 4μg/ml, >512μg/ml, 16μg/ml, >512μg/ml, 256μg/ml, 32μg/ml, 2μg/ml, 0.25μg/ml and 0.25μg/ml, respectively. This susceptibility pattern were very similar to the Toho-1 type β-lactamases producing strains.

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