Genetic Factors Influencing Irradiation Protection by Bone Marrow. III. Midlethal Irradiation of Inbred Mice

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Abstract
Results from inoculation of allogeneic marrow after midlethal irradiation in various donor-host combinations of inbred strains and F1 hybrids can he classified as follows: 1) an early lethal effect; 2) no beneficial or deleterious effect; 3) initial protection followed by late deaths; 4) lasting protection. These results depend on the strain combinations used. The early lethal effect in certain host-donor combinations was alteredby: delayed marrow inoculation, use of substrain C3HeB as the irradiated host, and preimmunization of the irradiated host. Certain host-donor combinations without early mortality presented evidence of reversal to host phenotype. This reversal was demonstrated by transplantation of reticuloendothelial tumors arising in the treated mice and by transplantation of strain-specific transplantable neoplasms.