A light and laser scanning microscopy study of bone/hydroxyapatite‐coated titanium implants interface: Histochemical evidence of unmineralized material in humans

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Abstract
The authors describe a light and laser scanning microscopy study of hydroxyapatite‐coated titanium implants retrieved from humans. A histochemical technique, using von Kossa and basic fuchsin, allowed clear differentiation between mineralized bone and unmineralized bone matrix. The bone‐hydroxyapatite (HA) interface presented variable features: in some areas the mineralized bone was directly apposed to the HA surface, while in others an unmineralized red‐stained material, probably osteoid, was interposed. Laser scanning microscopy confirmed these findings showing a thin layer of fluorescent material at the interface. © 1994 John Wiley & Sons, Inc.