400-MHz 1H N.M.R. of adjuvant muramyl dipeptide in dimethyl sulfoxide
- 1 January 1983
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 36 (6) , 1087-1096
- https://doi.org/10.1071/ch9831087
Abstract
The minimal active principle, N-acetylmuramyl-L-alanyl-D-isoglutamine* (MDP), of complete Freund's adjuvant was studied in dry dimethyl sulfoxide solutions by 1H n.m.r. at 400 MHz. All resonances except those of the non-anomeric CH protons of the sugar ring were assigned. The α/β anomeric ratio was found to be the same (2 : 1) as reported for the equilibrated aqueous solutions from which the dimethyl sulfoxide solutions were prepared. The present findings indicate that MDP adopts a substantially structured conformation in dimethyl sulfoxide solutions.Keywords
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