Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis
- 6 January 1999
- journal article
- research article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 72 (2) , 181-188
- https://doi.org/10.1002/(sici)1097-4644(19990201)72:2<181::aid-jcb3>3.0.co;2-d
Abstract
We have isolated a mouse lysyl oxidase‐like (LOXL) cDNA from a mouse embryo cDNA library and used this cDNA to measure changes in steady state levels of LOXL mRNA during the development of carbon tetrachloride‐induced liver fibrosis in adult mice. These results revealed the coincident appearance of increased steady state levels of LOXL mRNA and type III procollagen mRNA early in the development of liver fibrosis. In contrast, steady state levels of lysyl oxidase mRNA increased throughout the onset of hepatic fibrosis and appeared in parallel with the increased steady state levels of pro‐αI (I) collagen mRNA. These findings suggest that the LOXL protein (possibly an isoform of lysyl oxidase) is involved in the development of lysine‐derived cross‐links in collagenous substrates. Moreover, the substrate specificity of the LOXL protein may be different to that of lysyl oxidase and this difference may be collagen‐type specific. J. Cell. Biochem. 72:181–188, 1999.Keywords
This publication has 22 references indexed in Scilit:
- Congenital cutis laxa and lysyl oxidase deficiencyClinical Genetics, 1997
- A Homozygous Nonsense Mutation and a Combination of Two Mutations of the Wilson Disease Gene in Patients with Different Lysyl Oxidase Activities in Cultured FibroblastsJournal of Investigative Dermatology, 1997
- A New Gene with Sequence and Structural Similarity to the Gene Encoding Human Lysyl OxidaseJournal of Biological Chemistry, 1995
- Hepatic Fibrosis in Rats Produced by Carbon Tetrachloride and Dimethylnitrosamine: Observations Suggesting Immunoassays of Serum for the 75 Fragment of Type Iv Collagen Are A More Sensitive Index of Liver Damage Than Immunoassays for the Nh2–Terminal Propeptide of Type Iii ProcollagenHepatology, 1992
- The serum concentrations of the aminoterminal propeptide of procollagen type III and the hepatic content of mRNA for the α1 chain of procollagen type III in carbon tetrachloride-induced rat liver fibrogenesisJournal of Hepatology, 1991
- Lysyl Oxidase and rrg Messenger RNAScience, 1991
- Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- rasScience, 1990
- Secretion of lysyl oxidase by cultured human skin fibroblasts and effects of monensin, nigericin, tunicamycin and colchicineBiochimica et Biophysica Acta (BBA) - General Subjects, 1986
- CROSS-LINKING IN COLLAGEN AND ELASTINAnnual Review of Biochemistry, 1984
- Properties of highly purified lysyl oxidase from embryonic chick cartilageBiochimica et Biophysica Acta (BBA) - Enzymology, 1976