5′‐Nucleotidase immunoreactivity of perineuronal microglia responding to rat facial nerve axotomy
- 1 January 1992
- Vol. 6 (4) , 314-317
- https://doi.org/10.1002/glia.440060410
Abstract
The ecto-enzyme 5′-nucleotidase was localized immunocytochemically in the axotomized rat facial nucleus. As revealed by the monoclonal antibody 5N4–2,5′-nucleotidase immunoreactivity markedly increased on perineuronal microglia during the first week following axotomy, and gradually disappeared from these cells by the end of the third post-operative week. Interestingly, parenchymal microglia were not or only weakly stained. These findings indicate that 5′-nucleotidase 5N4-2-immunoreactivity may serve as a marker for perineuronal microglia, a population of satellite glial cells that appear to be actively engaged in lesion-induced synaptic changes during regeneration.Keywords
This publication has 31 references indexed in Scilit:
- Synaptic 5′-nucleotidase is transient and indicative of climbing fiber plasticity during the postnatal development of rat cerebellumDevelopmental Brain Research, 1991
- Extracellular ATP as a possible mediator of cell-mediated cytotoxicityImmunology Today, 1990
- The glycosyl-phosphatidylinositol anchor of membrane proteinsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
- Delayed astrocyte reaction following facial nerve axotomyJournal of Neurocytology, 1988
- 5′-Nucleotidase in postnatal ontogeny of rat cerebellum: a marker for migrating nerve cells?Developmental Brain Research, 1988
- Functional plasticity of microglia: A reviewGlia, 1988
- 5′-Nucleotidase of cerebellar molecular layer: Reduction in purkinje cell-deficient mutant miceDevelopmental Brain Research, 1986
- Enzyme changes in the rat facial nucleus following a conditioning lesionExperimental Neurology, 1984
- A monoclonal antibody inhibiting rat liver 5′-nucleotidaseFEBS Letters, 1981
- 5?-Nucleotidase of microglial cells in the facial nucleus during axonal reactionJournal of Neurocytology, 1978