THE AVERAGE DAILY ELIMINATION OF UROBILINOGEN IN HEALTH AND IN DISEASE, WITH SPECIAL REFERENCE TO PERNICIOUS ANEMIA

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Abstract
Relatively little use is made in clinical investigation of the considerable existing knowledge concerning the circulation and elimination of urobilinogen. This is not because of any general doubt about the significance of urobilin in the urine and feces, because the relationship of its concentration in these excreta to hepatic function, obstruction of the bile passages and destruction of the blood has been demonstrated repeatedly. Rather, the apathy in this regard may be attributed to the lack of any generally accepted method of quantitation and of exact knowledge concerning the daily output in health and disease. This report is the culmination of work begun three years ago, the purpose of which was to survey methods of estimation previously described in the literature and to use a method found to be reasonably accurate in ascertaining the average amount of urobilin eliminated per day in both normal and sick persons. HISTORICAL REVIEW Since

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