Studies on the Response of Liver Xanthine Oxidase to Dietary Protein in Weanling Rats

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Abstract
Earlier studies on the response of liver xanthine oxidase to various dietary proteins, using adult rats, have been extended to weanling rats in order to compare the growth response with the enzyme response in the same animals. A method of treating proteins which involves the addition of dilute alkali and autoclaving has been described. This treatment, originally intended to destroy vitamin B12, was found to enhance the xanthine oxidase response in rats fed the treated proteins. Growth response was also increased to some extent by the treatment. Under the conditions of these experiments the addition of molybdate did not alter the xanthine oxidase response constants of the proteins tested. A slight stimulatory effect of vitamin B12 on the xanthine oxidase response was observed for three of the proteins tested.