Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-ribofuranosyl]-3-N-methyl-thymine]-3′-spiro-5″-(4″-amino-1″,2″-oxathiole-
- 6 July 1993
- journal article
- research article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 46 (1) , 69-77
- https://doi.org/10.1016/0006-2952(93)90349-2
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- TSAO analogs. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)pyrimidine and pyrimidine-modified nucleosidesJournal of Medicinal Chemistry, 1992
- 3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2'', 2''-dioxide] (TSAO) pyrimidine nucleosidesJournal of Medicinal Chemistry, 1992
- [2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1Antimicrobial Agents and Chemotherapy, 1992
- Synthesis of {1-[2′,5′-Bis-O-(t-butyldimethylsilyl)-β-d-xylo- and β-d-ribofuranosyl]thymine}-3′-spiro-5″-{4″-amino-1″,2″-oxathiole-2″,2″-dioxide} (TSAO). A novel type of specific anti-HIV agentsTetrahedron Letters, 1992
- Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase InhibitorScience, 1990
- Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivativesNature, 1990
- Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivativeBiochemical and Biophysical Research Communications, 1989
- Determination of 2′,3′-dideoxyadenosine, 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine in biological samplesJournal of Chromatography B: Biomedical Sciences and Applications, 1988
- Thymidylate synthetase from amethopterin-resistant Lactobacillus casei. Purification by affinity chromatographyBiochemistry, 1974