Effect of Anti-Inflammatory Steroids on the Activity of Selected Lysosomal Hydrolases in Serum of Rats with Experimental Liver Fibrosis
- 17 July 1983
- journal article
- research article
- Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes
- Vol. 82 (04) , 111-114
- https://doi.org/10.1055/s-0029-1210265
Abstract
Liver fibrosis was produced in rats by subcutaneous injections of carbon tetrachloride. The effect of anti-inflammatory steroids (hydrocortisone, prednisone, dexamethasone) on the activity of serum lysosomal hydrolases (β-N-acetylglucosaminidase, β-glucosidase and α-mannosidase) was investigated in healthy and CC14 poisoned rats. The marked increase of enzymatic activity in blood serum was observed in animals with CC14-induced liver fibrosis. Quite opposite results were found in normal rats treated with glucoeorticosteroids. In rats which were given both carbon tetrachloride and corticosteroids the obtained values of serum enzymatic activity did not have a uniform character as compared to controls or CCl4 intoxicated rats. Presumable mechanisms of the results obtained are discussed.Keywords
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