Efficacy of 2-month total parenteral nutrition in AIDS patients

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Abstract
Objective To evaluate the efficacy of total parenteral nutrition in AIDS patients. Design A prospective, randomized, controlled, multicenter trial. Methods Over a period of 2 months. 81 malnourished and severely immunodepressed AIDS patients were assigned to reserve either dietary counseling in 15 or home total parenteral nutrition TPNn via central venous access after an educational program Results were analysed by intent-to treat basis. Results Bodyweight change was +8 kg ± in the TPN group and kg 6 ± 2% in the control group (P 0.0006 lean body mass increased in the TPN group 19 ± and decreased in the control group 5± P 0.004 while body cell mass increased in the former ± 4 and decreased in the latter: 12 ± 6% P 0.002 Nutritional subjective global assessment subjective self reported health feeling and Karnofsky index were also improved by JPN Infection line sepsis incidence remained loss 0.26 per 100 patient-days. However no difference in survival rate was exhibited between the two groups by the log-rank test. Conclusion We conclude that home IPN is an efficient treatment of malnutrition in severely immunodepressed AIDS patients.

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