The Effects of Terbutaline on the Acid Base Balance and Circulation of Chronically Instrumented Pregnant Sheep

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Abstract
Terbutaline is considered an effective β agonist with β2 character, for the inhibition of labor. Its safety was evaluated in twelve infusions of 1,500 µg over 30 min, to 8 ‘steady state’ pregnant sheep of 110-134 days of gestation. Experimentation was performed at least 4 days postoperatively. Maternal (n = 12) and fetal (n = 7) arterial blood samples were drawn at 0, 10, 20, 30, 60 and 90 min from the start of the infusion. Uterine blood flow (UBF), blood pressure (BP), and heart rate (HR) were monitored continuously. Maternal pCO(2), bicarbonate (HCO(3)), and base excess (BE) decreased significantly during the infusion. Maternal pH, pO(2), and O(2)% saturation of the hemoglobin (O(2)%) remained constant. Maternal hemoglobin (Hb) increased significantly at 10 min. A significant maternal hypotension and tachycardia followed the infusion. UBF decreased by 26% at the end of infusion, recovering by 60 min. Fetal pH, pCO(2), Hb, O(2)%, BP, HR, HCO(3), BE, and CO(2) content all remained stable for the duration of the experiment. Fetal arterial pO(2) transiently increased at 10 min. No other significant fetal effects were observed.

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