Comparative in Vitro Activity of Augmentin Against Community and Hospital-Acquired Gram-Negative Bacteria

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Abstract
The susceptibility of 841 unselectcd, gramnegative bacterial isolates to augmentin, an amoxycillin/clavulanic acid formulation, was examined and compared with their sensitivity to other antibiotics. Susceptibility was measured using a disk diffusion procedure. Augmentin showed a high degree of activity against the folates tested. Overall rates of sensitivity, intermediate sensitivity, and resistance to augmentin among the Enlerobacleriaceae were 81.6%, 7.6%, and 10.8%, respectively. As expected, a considerably higher degree of resistance occured to ampicillin (58.4 %). The antibacterial pattern augmentin compared favourably with that of the second-generation cephalosporin, cefuroxime. These results indicate that augmentin is likely to be clinically active against a conquerable number of community and hospital-acquired gram-negative strains.

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