A forty-year memoir of research on the regulation of glucose transport into muscle
- 1 March 2003
- journal article
- autobiography
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 284 (3) , E453-E467
- https://doi.org/10.1152/ajpendo.00463.2002
Abstract
This historical review describes the research on the regulation of glucose transport in skeletal muscle conducted in my laboratory and in collaboration with a number of colleagues in other laboratories. This research includes studies of stimulation of glucose transport, GLUT4 translocation, and GLUT4 expression by exercise/muscle contractions, the role of Ca2+in these processes, and the interactions between the effects of exercise and insulin. Among the last are the additive effects of insulin and contractions on glucose transport and GLUT4 translocation and the increases in muscle insulin sensitivity and responsiveness induced by exercise.Keywords
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