A Simple Synthetic Method of trans-5-Aryl and 5-Cyclopropyl Derivatives of 2-Isoxazolin-4-ol via Intramolecular Ring Opening of α,β-Epoxy Ketone Oximes

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Abstract
trans-5-Aryl and 5-cyclopropyl derivatives of 2-isoxazolin-4-ol were conveniently prepared from trans-2-aryl- and 2-cyclopropyl-3-benzoyloxiranes and hydroxylamine hydrochloride in the presence of pyridine via an intramolecular opening of oxirane by the oxygen nucleophile of the oxyimino group.

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