Chemical structural requirement in gingerol derivatives for potentiation of prostaglandin F2.ALPHA.-induced contraction in isolated mesenteric veins of mice.

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Abstract
We have previously reported that (.+-.)-[6]- and (.+-.)-[8]-gingerols potentiate prostaglandin (PG) F2.alpha.-induced muscle contraction, and that other gingerol-related derivatives do not necessarily produce the same effect. The moiety necessary for potentiation was therefore investigated. 1) (.+-.)-[8]-Gingerol potentiated PGF2.alpha.-induced contraction to a greater extent than (.+-.)-[6]-gingerol and [.+-.) hexahydrocurcumine (HHC), but [6]-shogaol produced inhibition; 2) Noradrenaline (NA)-induced contraction was inhibited in the following order: [6]-shogaol > (.+-.)- [8]-gingerol > [6]-gingerdione > [.+-.)-[6]-gingerol > S-(.female.)-[6]-gingerdiacetate (GDA) > [6]-dehydrogingerdione (DHG), whereas (.+-.)-HHC had no significant inhibitory action; 3) [6]-gingerdione had different effects on PGF2.alpha.-induced contraction, indicating inhibition just after preparation of the solution, no effect apparent after 2 h, and potentiation after 5 h; 4) [6]-gingerdione showed a change in its chemical structure after 5 h as measured by the FeCl3 reaction, and ultraviolet and 1H nuclear magnetic resonance spectra. It was concluded that the aliphatic hydroxyl group present in gingerol derivatives is necessary for potentiation of PGF2.alpha.- and the keto group for inhibition of NA-induced contraction.

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