Lipid Metabolism in Peripheral Nerve Cell Culture (Rich in Schwann Cells) from Normal and Trembler Mice

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Abstract
A culture of peripheral nerve cells, very rich in Schwann cells, was developed from sciatic nerve. In both normal and Trembler, typical spindle-shaped cells were seen. Most of the cells were surrounded by basement membrane-like material (predominantly in-between adjacent cells). In Trembler cells, cultivated in the presence of labeled acetate, the fatty acids were slightly altered. Phosphatidylcholine was slightly reduced and phosphatidylethanolamine increased. Sulfatides were increased 4 times.