Amygdala BDNF signaling is required for consolidation but not encoding of extinction
- 18 June 2006
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 9 (7) , 870-872
- https://doi.org/10.1038/nn1718
Abstract
Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.Keywords
This publication has 16 references indexed in Scilit:
- BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesisProgress in Neurobiology, 2005
- Cognitive Enhancers as Adjuncts to PsychotherapyArchives of General Psychiatry, 2004
- Facilitation of Memory for Extinction of Drug-Induced Conditioned Reward: Role of Amygdala and AcetylcholineLearning & Memory, 2004
- Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Involvement in Amygdala-Dependent Fear ConditioningJournal of Neuroscience, 2004
- Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies.2003
- Faculty Opinions recommendation of Regulation of synaptic plasticity genes during consolidation of fear conditioning.Published by H1 Connect ,2002
- Neurons in medial prefrontal cortex signal memory for fear extinctionNature, 2002
- L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in MiceJournal of Neuroscience, 2002
- The endogenous cannabinoid system controls extinction of aversive memoriesNature, 2002
- trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.Molecular and Cellular Biology, 1991