Inhibitors of folate biosynthesis. 1. Inhibition of dihydroneopterin aldolase by pteridine derivatives
- 1 September 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (9) , 1213-1215
- https://doi.org/10.1021/jm00219a021
Abstract
2-Amino-6-carboxamido-7,8-dihydropteridin-4-one and 2-amino-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin-4-one apparently were good inhibitors of Escherichia coli dihydroneopterin aldolase, an early enzyme of de novo folate biosynthesis.This publication has 1 reference indexed in Scilit:
- THE STRUCTURE OF 2-AMINO-4-HYDROXY-6-SUBSTI-TUTED-DIHYDROPTERIDINE DERIVATIVES PREPARED BY REDUCTION WITH HYDROSULFITETHE JOURNAL OF VITAMINOLOGY, 1966