The retention of metabolic radioactive carbonate

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Abstract
A method for calculating the distribution of C14 bicarbonate in an idealized "3-compartment" animal is given. The procedure was demonstrated in detail, using the data of Kornberg. Different equations are required to express the retention of C14O2 formed uniformly throughout the soft tissues and the retentions of C14O2 arising, or injected into, the blood. The parameters of the "soft tissue" equation are derivable from those of the "blood" equation. Measurements of the ratio of C14O2 expired to the total C14O2 of the body gives information as to whether C14O2 is produced throughout the soft tissues or only in a small portion of them. In the latter case, the retention is more nearly described by the "blood" equation.