Highly regioselective formation of bromohydrins by reaction of epoxy-azetidinones with MgBr2: An alternative route to 4-bromomethylcarbonylmethyl-2-azetidinone, a key carbapenem precursor
- 1 January 1988
- journal article
- Published by Elsevier in Tetrahedron Letters
- Vol. 29 (41) , 5197-5200
- https://doi.org/10.1016/s0040-4039(00)80715-7
Abstract
No abstract availableThis publication has 10 references indexed in Scilit:
- A highly stereoselective conversion of α,β-epoxy esters to α-hydroxy esters. An efficient route to optically active α-hydroxyestersTetrahedron Letters, 1987
- From Penicillin to Penem and Carbapenem. VIII. Introduction of an Allyl Group at the C-4 Position of the Azetidinone Molecule, and the Synthesis of DethiathienamycinBulletin of the Chemical Society of Japan, 1986
- Titanium isopropoxide-mediated nucleophilic openings of 2,3-epoxy alcohols. A mild procedure for regioselective ring-openingThe Journal of Organic Chemistry, 1985
- Nucleophilic opening of 2,3-epoxy acids and amides mediated by titanium isopropoxide. Highly enhanced C-3 selectivityThe Journal of Organic Chemistry, 1985
- Synthesis of 3-aminoalkyl substituted carbapenems via a phosphorane intermediateTetrahedron Letters, 1985
- Synthesis of Carbaoenems with a RXCH2-Substituent in the 3-PositionHETEROCYCLES, 1985
- Stereospecific synthesis of chiral precursors of thienamycin from L-ThreonineTetrahedron, 1984
- Syntheses and biological activities of new carbapenem derivatives.The Journal of Antibiotics, 1984
- Dilithium tetrabromonickelate (II) as a source of soft nucleophilic bromide : Reaction with epoxidesTetrahedron Letters, 1984
- The Reaction between Grignard Reagents and the Oxirane Ring.Chemical Reviews, 1951