Stereoselective Synthesis and Antimalarial Activity of α-Artelinic Acid from Artemisinin

1 August 1992

journal article
Published by American Chemical Society (ACS) in Journal of Natural Products

Vol. 55 (8) , 1142-1144
https://doi.org/10.1021/np50086a018

Abstract

Alpha-Artelinic acid [8], a potent, stable, and water-soluble antimalarial agent, has been synthesized from artemisinin [1], the sesquiterpene lactone endoperoxide isolated from Artemisia annua. The blood schizontocidal antimalarial activity of alpha-artelinic acid evaluated against Plasmodium knowlesi is also reported.

Keywords

ANTIMALARIAL ACTIVITY
ARTELINIC ACID
ARTEMISIA
ANNUA
PLASMODIUM
KNOWLESI
LACTONE

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