The Double Annulation of Tethered Diacids and Alkynones: History and Scope
- 2 January 2001
- journal article
- account
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2001 (01) , 0013-0021
- https://doi.org/10.1055/s-2001-9690
Abstract
The double Michael reaction of a tethered carbon diacid (a 1,n-dinucleophile) with an alkynone (a 1,1-dielectrophile) provides highly substituted and functionalized monocyclic double Michael adducts in what is formally an [n + 1] annulation. The pendant functionality in the double Michael adduct can be used to effect a second annulation. A history and overview of the "double annulation" route to bicyclic compounds is presented. The scope and selectivity of the route is also discussed.Keywords
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