Improved Aldehyde Synthesis: Preparation of 3?, 7?, 12?-Triacetoxy-5?-Cholan-23-al with Ruthenium Tetroxide in Neutral Medium
- 1 January 1973
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 3 (4) , 287-291
- https://doi.org/10.1080/00397917308065918
Abstract
In relation to our studies on the metabolism of neutral sterols2 we have prepared several substituted 24-norcholanic acids. Ruthenium tetroxide was selected as the oxidizing agent3,4 in the formation of 24-norcholic acid5,6 from the olefin, 3α, 7α, 12α-triacetoxy-24, 24-diphenyl-5β-chol-23-ene (II), (Fig. 1) since CrO3 provided multiple products5.Keywords
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