Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial
- 26 August 2005
- journal article
- research article
- Published by Taylor & Francis in Current Medical Research and Opinion
- Vol. 21 (10) , 1683-1692
- https://doi.org/10.1185/030079905x65439
Abstract
Objectives: To compare change from baseline in HIV RNA and fasting low-density lipoprotein (LDL) cholesterol levels in protease inhibitor (PI)–experienced patients receiving unboosted atazanavir 400 mg once daily versus lopinavir 400 mg boosted with ritonavir 100 mg twice daily, with two nucleoside reverse transcriptase inhibitors (NRTIs). Secondary objectives included virologic response, CD4 cell count changes, other lipid changes, safety, and tolerability.Methods: Randomized, open-label, multinational, 48-week study in patients with one PI-regimen failure, HIV RNA ≥ 1000 copies/mL, and CD4 count ≥ 50 cells/mm3.Results: Three hundred patients were randomized; 290 treated (144 atazanavir, 146 lopinavir/ritonavir). Lopinavir/ritonavir resulted in a significantly greater reduction in HIV RNA than unboosted atazanavir (–2.02 vs –1.59 log10 copies/mL, p < 0.001) at week 48. Secondary efficacy endpoints also favored lopinavir/ritonavir; the differences in efficacy between regimens were also observed in...Keywords
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