Endogenous Cyclic Adenosine Monophosphate in Tissues of Rabbits Fed an Atherogenic Diet
- 7 February 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 187 (4175) , 449-450
- https://doi.org/10.1126/science.163039
Abstract
Rabbits fed a high cholesterol diet experienced a significant increase in plasma adenosine 3′,5′-monophosphate (cyclic AMP), which was simultaneous with the increase in plasma cholesterol. The content of cyclic AMP in atherosclerotic lesion areas of rabbit aortic intima-media was significantly higher (0.24 picomole per microgram of DNA) than that in adjacent nonlesion areas or in aortic intima-media from control animals (0.09 picomole per microgram of DNA). The cyclic AMP content of heart, liver, skeletal muscle, and diaphragm showed no significant elevation in animals fed cholesterol.Keywords
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