Biotin and the nucleophilicity of 2-methoxy-2-imidazoline toward the sp 2 carbonyl carbon

1 January 1969

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society D: Chemical Communications

No. 20,p. 1173-1174
https://doi.org/10.1039/c29690001173

Abstract

A model for the biotin tautomer, 2-methoxy-2-imidazoline, possesses a nucleophilicity toward the sp² carbonyl carbon 10¹⁰-fold greater than the previously considered 2-imidazolidone.

Keywords

MODEL
NUCLEOPHILICITY
BIOTIN TAUTOMER
SP2 CARBONYL
GREATER THAN
FOLD GREATER
PREVIOUSLY CONSIDERED
IMIDAZOLIDONE

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